What Happens When Lymphocytes Count Is High: Causes, Symptoms and Treatment

Lymphocytes, a type of white blood cell, play a crucial role in the immune system and help the body fight against infections, diseases and cancerous cells. Abnormalities in the count of lymphocytes can indicate underlying medical conditions and require attention from medical professionals. High lymphocyte count, also known as lymphocytosis, is one such abnormality that needs to be addressed promptly. In this blog post, we will explore the causes, symptoms and treatment options for high lymphocyte count. So, if you or someone you know has recently been diagnosed with high lymphocyte count or wants to learn more about it, keep reading to discover more.

Understanding Lymphocytes and Their Role in the Body

Lymphocytes are a type of white blood cell that plays an essential role in the immune system. They aid in fighting off infections and diseases by recognizing and attacking foreign substances in the body. These specialized cells are produced in the bone marrow and can be found circulating throughout the bloodstream, lymphatic system, and various tissues.

There are two primary types of lymphocytes: T-cells and B-cells. T-cells are responsible for recognizing and destroying infected or cancerous cells in the body, while B-cells produce antibodies that target specific pathogens. Together, these cells work to protect our bodies from harmful invaders and maintain overall health.

One critical aspect of lymphocytes is their count. The number of lymphocytes present in the blood can provide insight into the state of a person’s immune system. A high lymphocyte count may indicate an infection, an autoimmune disorder, or even cancer. Conversely, a low lymphocyte count may suggest weakness in the immune system, making individuals more susceptible to illnesses.

In summary, understanding lymphocytes and their role in the body is crucial in maintaining overall health and well-being. By monitoring lymphocyte count levels and taking steps to keep our immune system healthy, we can help protect our bodies from harmful pathogens and diseases.

Causes of High Lymphocyte Count

One of the most common causes of high lymphocyte count is infection. This happens because lymphocytes, white blood cells that play a crucial role in the immune system, increase in number to fight off any foreign invaders. Viral infections such as mononucleosis, hepatitis, measles or HIV can lead to an increase in lymphocyte count.

Autoimmune diseases are another potential cause of high lymphocyte count. These conditions occur when the immune system mistakenly attacks healthy cells and tissues in the body, causing inflammation and damage. Examples of autoimmune diseases include lupus, rheumatoid arthritis, and multiple sclerosis.

Cancer can also cause an increase in lymphocyte count. In some cases, cancer cells can stimulate the production of lymphocytes, leading to elevated levels. Leukemia, lymphoma, and Hodgkin’s disease are types of cancers that can affect lymphocytes.

Stress, both physical and emotional, can also be a factor in high lymphocyte count. When the body undergoes stress, it releases various hormones, one of which is cortisol. Cortisol can stimulate the production of lymphocytes, leading to higher levels. However, chronic stress can have the opposite effect and actually decrease lymphocyte count over time.

Lastly, certain medications can cause an increase in lymphocyte count. Drugs used to treat inflammatory diseases like rheumatoid arthritis, psoriasis, and asthma can trigger the immune system to produce more lymphocytes. Immunosuppressant drugs can also cause an increase in lymphocyte count as they work by suppressing the immune system.

It’s important to note that a high lymphocyte count may not always be indicative of a serious medical condition. However, if you experience symptoms such as fever, fatigue, swollen lymph nodes, joint pain or skin rash, it’s best to consult with a healthcare professional to determine the underlying cause and appropriate treatment.

Symptoms of High Lymphocyte Count

Symptoms of High Lymphocyte Count

A high lymphocyte count, also known as lymphocytosis, can be an indication of an underlying medical condition. In some cases, it may not cause any symptoms and only be detected through routine blood tests. However, in other instances, a high lymphocyte count can cause a range of symptoms such as:


Fever is a common symptom of a high lymphocyte count. It occurs when the body’s temperature rises above its normal range, which is usually 98.6°F (37°C). A fever is often a sign that the body is fighting off an infection or inflammation.


Feeling tired or weak is another common symptom of a high lymphocyte count. This can happen because the immune system is working overtime to combat the underlying issue, leaving the individual feeling drained and exhausted.

Swollen Lymph Nodes

Lymph nodes are small, bean-shaped structures that are located throughout the body. They play a vital role in the immune system by filtering out harmful substances. When lymphocytes are activated, they can cause the lymph nodes to swell. This can occur in different parts of the body, including the neck, underarms, and groin.

Joint Pain

Inflammation caused by a high lymphocyte count can result in joint pain. This is especially true in autoimmune diseases where the body mistakenly attacks its own tissues. Joint pain can be debilitating and make it difficult for individuals to move around comfortably.

Skin Rash

Another symptom of a high lymphocyte count is a skin rash. This can occur due to an allergic reaction or inflammation caused by autoimmune disorders. The rash may be itchy, red, and scaly and can appear anywhere on the body.

It’s important to note that these symptoms are not unique to a high lymphocyte count and can occur due to various other conditions. If you experience any of these symptoms, it’s crucial to consult a healthcare professional to determine the underlying cause and receive appropriate treatment.

Diagnosis and Treatment of High Lymphocyte Count

When a high lymphocyte count is detected, the next step is to determine the underlying cause so that appropriate treatment can be given. The diagnosis of high lymphocyte count typically involves a physical examination and blood tests.

A complete blood count (CBC) is the most common test used to diagnose high lymphocyte count. This test measures the number of white blood cells, red blood cells, and platelets in the blood. An elevated white blood cell count, particularly an increase in lymphocytes, may indicate an infection, inflammation or an autoimmune disease.

In addition to CBC, other blood tests may also be ordered to help identify the cause of high lymphocyte count. These may include tests for infectious diseases such as HIV, hepatitis, and tuberculosis. Blood tests to check for abnormal levels of chemicals and proteins in the blood that are associated with cancer may also be utilized.

Once the underlying cause of the high lymphocyte count has been determined, appropriate treatment can be given to address it. Treatment options may vary depending on the cause of the condition. For example, if the high lymphocyte count is caused by an infection, antibiotics may be prescribed to treat the infection. If the high lymphocyte count is caused by cancer, chemotherapy may be used to kill cancer cells.

Immunosuppressive drugs may also be prescribed in cases where the high lymphocyte count is due to an autoimmune disorder. These drugs work by weakening the immune system, which helps to reduce inflammation and prevent damage to healthy tissues.

It’s important to note that the treatment of high lymphocyte count must always be tailored to the individual based on their specific medical history and current condition. Therefore, it is imperative that individuals seek proper medical attention and follow the advice of healthcare professionals to obtain optimal results.
A high lymphocyte count is not a disease in itself, but it can indicate an underlying issue with the body’s immune system. Understanding what causes this condition and its symptoms is critical for timely diagnosis and treatment. Infections, autoimmune diseases, cancer, stress, and medications are just some of the factors that can affect lymphocyte counts. While treatments may vary depending on the underlying cause, early detection and prompt treatment are crucial for managing conditions that cause high lymphocyte counts. If you experience any symptoms or have concerns about your health, consult with your healthcare provider as soon as possible. By taking proactive steps to care for our bodies, we can help ensure optimal health and well-being.

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